After Brianna O<U+2019>Brien kills herself, Dr. David Spears blames himself. When David believes Brianna's friend, Amka Obed, whom he's also been treating virtually, is struggling, he goes to Utqiagvik, Alaska, only to find out that she has disappeared. David and the town's social worker, Taylor Holmes, start an investigation into Amka's disappearance. David wonders if a new antidepressant he recently prescribed Amka and Brianna played a part in what took place. While Taylor suspects a drug lord with ties to Amka's boyfriend.